Autologous skin cell spray-transplantation for a deep dermal burn patient in an ambulant treatment room setting.
نویسندگان
چکیده
Jörg C. Gerlach *, Christa Johnen , Eric McCoy , Kirsten Bräutigam , Jörn Plettig , Alain Corcos c Departments of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA Charité, Campus Virchow, AG Experimental Surgery, University Medicine Berlin, Berlin, Germany University of Pittsburgh Medical Center, UPMC Mercy Hospital Burn Center, Pittsburgh, PA, USA Stem Cell Systems, Berlin, Germany b u r n s 3 7 ( 2 0 1 1 ) e 1 9 – e 2 3
منابع مشابه
Keratinocytes in Tissue Engineering of human skin: in Vitro and in Vivo Studies
Full thickness wounds, such as deep burns, need restoration of both the dermal and epidermal layers of the skin. In normal wound healing, re-epithelialization occurs by migration and proliferation of keratinocytes from the wound edges and by differentiation of stem cells from remaining hair follicles. Restoration of dermis occurs by influx of growth factors secreted by macrophages, platelets, a...
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The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that bu...
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Deep dermal partial-thickness scalds remain one of the most common types of injuries in childhood. Local treatment of those wounds, alternatively described as IIb degree, is still very controversial. Some authors advise conservative treatment of such wounds, pointing to their ability to self-reepithelialise, which is possible but significantly prolonged. Other investigators postulate operative ...
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BACKGROUND Keratinocyte cultures have been used for the treatment of severe burn patients. Here, we describe a new cultured bioengineered skin based on (1) keratinocytes and fibroblasts obtained from a single skin biopsy and (2) a dermal matrix based on human plasma. A high expansion capacity achieved by keratinocytes grown on this plasma-based matrix is reported. In addition, the results of su...
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Autologous skin-grafting is the gold standard for treatment of deep second and third degree burns. Available bioengineered skin products also necessitate this two-step surgical procedure. Therefore, we developed fetal skin constructs to improve healing of such degree burns. A bank of fetal skin cells was developed from one organ donation (4 cm2 of skin allowing the preparation of several millio...
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ورودعنوان ژورنال:
- Burns : journal of the International Society for Burn Injuries
دوره 37 4 شماره
صفحات -
تاریخ انتشار 2011